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2,6-Difluorobenzamide

Name: 2,6-Difluorobenzamide
Brand: Royalchem
Rating: 5.0 (49 reviews)

Model: High-Purity Agrochemical Intermediate ≥99.5%
Brand: Royalchem
Code: 18063-03-1

Product Description

Reference Properties

Physical State	Solid
Reference Melting Point	Approx. 144–147°C

Reference physical properties are provided for substance identification and are not fixed Royalchem release specifications.

Applications in Benzoylurea Insecticide Synthesis

Diflubenzuron	Published manufacturing routes use 2,6-Difluorobenzamide directly with the corresponding aryl isocyanate intermediate to construct the benzoylurea structure of Diflubenzuron.
Hexaflumuron	2,6-Difluorobenzamide can be converted to 2,6-Difluorobenzoyl Isocyanate and subsequently coupled with the appropriate substituted aniline intermediate in Hexaflumuron synthesis. Direct coupling routes through the complementary aryl isocyanate are also reported.
Chlorfluazuron	Published processes convert 2,6-Difluorobenzamide to 2,6-Difluorobenzoyl Isocyanate before coupling with the corresponding substituted aromatic amine intermediate.
Lufenuron	Published Lufenuron processes react an appropriate aryl isocyanate intermediate with 2,6-Difluorobenzamide to form the target benzoylurea structure.

Why Does the Impurity Profile Matter?

For process-sensitive benzoylurea synthesis, assay alone may not fully describe raw-material suitability. Process-related impurities such as 2,6-Difluorobenzoic Acid, residual 2,6-Difluorobenzonitrile, related benzamides and individual unknown impurities may influence downstream reaction behavior and purification requirements. Customers are therefore encouraged to compare the complete target specification and batch COA.

Typical Synthesis Chain

Upstream	2,6-Difluorobenzonitrile can be hydrolyzed to produce 2,6-Difluorobenzamide.
Core Intermediate	2,6-Difluorobenzamide (CAS 18063-03-1)
Activated Intermediate	Selected routes convert the product to 2,6-Difluorobenzoyl Isocyanate using suitable carbonylating reagents before downstream coupling.
Typical Downstream	Diflubenzuron, Hexaflumuron, Chlorfluazuron and Lufenuron related manufacturing routes.

Sourcing High-Purity 2,6-Difluorobenzamide for Benzoylurea Synthesis?

Royalchem supplies2,6-Difluorobenzamide (CAS 18063-03-1)with a current published typical assay of≥99.5%.

For Diflubenzuron, Hexaflumuron, Chlorfluazuron, Lufenuron and related agrochemical projects, please provide:target assay, known impurity limits, single-unknown impurity limit, moisture requirement, downstream product, quantity and destination country.

The applicablebatch COA, SDS, specification and packagingcan be confirmed according to the actual commercial supply source.

Frequently Asked Questions

What is CAS 18063-03-1?	CAS 18063-03-1 is 2,6-Difluorobenzamide, a fluorinated benzamide intermediate widely used in benzoylurea insecticide synthesis.
What is 2,6-Difluorobenzamide used for?	Its major agrochemical use is as an intermediate for benzoylurea insecticide synthesis, including published routes associated with Diflubenzuron, Hexaflumuron, Chlorfluazuron and Lufenuron.
Is 2,6-Difluorobenzonitrile the same product?	No. 2,6-Difluorobenzonitrile is a separate compound and a documented upstream starting material for preparing 2,6-Difluorobenzamide by hydrolysis.
What is the relationship with 2,6-Difluorobenzoyl Isocyanate?	2,6-Difluorobenzamide can be converted to 2,6-Difluorobenzoyl Isocyanate, an activated intermediate used in several benzoylurea insecticide manufacturing routes.
Why should buyers review the full impurity profile?	Different production routes can generate residual nitrile, difluorobenzoic acid and structurally related impurities. For process-sensitive applications, these impurities may affect reaction performance and downstream purification, so assay alone may not be sufficient for grade selection.
What is the reference melting point?	Current reference data gives a melting-point range of approximately 144–147°C. This is a reference physical property rather than a fixed Royalchem release specification.
What information should I provide for a quotation?	Please provide the target assay, known and unknown impurity limits, moisture requirement, downstream product, required quantity and destination country. A target COA can also be provided for specification matching.