5-Fluorouracil

• Appearance: White or practically white, crystalline powder

• Assay (HPLC): ≥ 99.0% (Dried Basis)

• Loss on Drying: ≤ 0.5%

• Residue on Ignition: ≤ 0.1%

• Heavy Metals: ≤ 20 ppm

• Melting Point: 280°C - 282°C (Decomposes)

• Solubility: Sparingly soluble in water; slightly soluble in alcohol.

A pyrimidine analogue that acts as an antimetabolite:

• Antineoplastic API: Inhibits thymidylate synthase (TS), blocking DNA synthesis. Widely used in chemotherapy for colorectal, breast, and skin cancers.

• Synthesis Intermediate: Key precursor for the synthesis of Flucytosine (5-FC) and other fluorinated nucleosides.

• Research Grade: Used in biochemical studies of nucleic acid metabolism and plant growth differentiation (e.g., rice/wheat genetic metabolism).