Product Category

Pharmaceutical and Intermediates

Support Material for The Isolation of Nucleic Acids

Bio-Renewable & Sustainable Solutions

Tetrahydrofuran (THF)

Model: ≥99.95%
Brand: Royalchem
Code: 109-99-9

Product Description

Product Name	Tetrahydrofuran (THF) CAS 109-99-9 \| EC No. 203-726-8 Synonyms: oxolane, tetramethylene oxide, 1,4-epoxybutane, BHT-stabilized THF
Formula / MW	C₄H₈O (cyclic (CH₂)₄O) / 72.11
Structure
Product Type	BHT-stabilized, high-purity cyclic ether solvent. It dissolves both polar and non-polar materials and coordinates metal ions, which makes it the standard solvent for Grignard and organometallic chemistry and the feedstock for PTMEG.
Specification	Appearance: clear, colorless, volatile liquid Assay (GC): ≥ 99.95% Water: ≤ 100 ppm Color (Pt-Co): ≤ 5 Peroxides (as H₂O₂): ≤ 50 ppm Stabilizer (BHT): 180 – 250 ppm Boiling point approx. 66 °C; flash point approx. −14 °C (closed cup); density approx. 0.888 g/cm³ at 20 °C; miscible with water (literature) Typical values; the batch COA governs.
Applications	PTMEG, spandex and polyurethane: raw material for polytetramethylene ether glycol (PTMEG), used in spandex fibers and polyurethane elastomers; assay, water, color and peroxides drive batch consistency Grignard and organometallic reactions: coordinating reaction solvent for Grignard reagents, organolithium chemistry, hydride reductions and other fine-chemical synthesis Pharmaceutical and fine-chemical processing: reaction, process and extraction solvent in API and intermediate synthesis; suitability depends on the customer's process and regulatory requirements PVC cements, coatings and inks: solvent for PVC pipe-jointing cements, coatings, printing inks, films and resins
Packing & Storage	Steel drums or ISO tanks, according to order quantity. Keep tightly closed in a cool, well-ventilated flammable-liquids store, away from heat, sparks, static and strong oxidizers. Minimize air contact and monitor peroxide levels; never distill to dryness. UN 2056, Class 3, Packing Group II.

Sourcing tetrahydrofuran?
Royalchem supplies Tetrahydrofuran (THF, CAS 109-99-9), assay ≥99.95%, water ≤100 ppm, BHT-stabilized, with batch COA, SDS and UN 2056 dangerous-goods documents. Please state your application, water/peroxide/BHT requirements, packaging and quantity.
Related solvents: DMSO, Acetonitrile and NMP.

FAQ

What is tetrahydrofuran?	Tetrahydrofuran (THF, oxolane, CAS 109-99-9, C₄H₈O, MW 72.11) is a volatile cyclic ether solvent, miscible with water, used to make PTMEG and as a solvent in organic synthesis, pharmaceutical processing and PVC cements.
Why is BHT added to THF?	THF can form hazardous peroxides during storage in contact with air. BHT is added as a stabilizer to slow peroxide formation; it does not replace correct storage and periodic peroxide checks.
Stabilized or inhibitor-free anhydrous THF: which do I need?	This page covers BHT-stabilized THF with water ≤100 ppm. For moisture- or inhibitor-sensitive chemistry, such as some Grignard and organolithium steps, check the water, peroxide and BHT limits against your process. Inhibitor-free anhydrous grades need different packaging and handling and are not interchangeable.
Is THF the same as 2-MeTHF or THFA?	No. 2-Methyltetrahydrofuran (2-MeTHF, CAS 96-47-9) is a related but different ether solvent, and THFA usually means tetrahydrofurfuryl acrylate (CAS 2399-48-6), a UV-curing monomer, or tetrahydrofurfuryl alcohol (CAS 97-99-4). Always check the CAS number.
Is THF a dangerous good?	Yes. THF is a highly flammable liquid: UN 2056, Class 3, Packing Group II. Each shipment goes with the batch SDS and dangerous-goods documents.

Product Category

Tetrahydrofuran (THF)

Product Description

FAQ

Contact us