Click chemistry

Dibenzocyclooctyne (DBCO) is used for the azide alkyne cycloaddition (SPAAC) reaction without the catalysis of copper ions. DBCO series products include DBCO- acid, DBCO-amine, DBCO-PEG-COOH, DBCO-PEG-amine, and DBCO labeled biotin, fluorescent dyes and biochemical small molecules that can be used for further connection.

DBCO (dibenzocyclooctyne) PEG is a heterobifunctional reactive PEG derivative that can go Click Chemistry reaction without a need of any metal catalysts. The strain-promoted 1,3-dipolar cycloaddition of cyclooctynes and azides, also termed as the Cu-free click reaction, is a bioorthogonal reaction that enables the conjugation of two molecules in aqueous solution. DBCO PEG derivatives possess fast kinetics and stability in aqueous buffer. DBCO reagents can be used to label azide-modified biomolecules spontaneously without the need for toxic Cu catalysts.

We can provide these products：

DBCO-PEG-amines

DBCO-PEG-carboxylic acid

DBCO-PEG-alcohols

DBCO-PEG-NHS

DBCO-PEG-Drugs (ADC class)

Other functionalized DBCO blocks

N3-PEG-Amines

N3-PEG-carboxylic acid

N3-PEG-Alcohols

N3-PEG-NHS

Other functionalized N3-blocks

If you need more information, we are at your disposal.