Insights on Alpha-(2,4-Dichlorophenyl)-2-(1H-imidazole-1-yl) ethanol

Introduction

Alpha-(2,4-Dichlorophenyl)-2-(1H-imidazole-1-yl) ethanol (CAS 24155-42-8) is a strategically important intermediate in pharmaceutical and agrochemical manufacturing. This technical analysis examines its properties, industrial applications, and manufacturing considerations for enterprise-scale production environments.

Chemical Properties

Alpha-(2,4-Dichlorophenyl)-2-(1H-imidazole-1-yl) ethanol has a molecular formula of C11H10Cl2N2O and a molecular weight of 257.12 g/mol. The chemical structure features a 2,4-dichlorophenyl group attached to an imidazole ring, which is further connected to an ethanol moiety. These structural features contribute to its utility in various applications.

Molecular Information:

• Formula: C₁₁H₁₀Cl₂N₂O

• Molecular Weight: 257.12 g/mol

• Structure: 2,4-dichlorophenyl group bonded to an imidazole-ethanol moiety

• Physical Form: White to off-white crystalline solid

• Melting Point: 134–138 °C

• Typical Commercial Purity: ≥ 99.0%

Applications and Downstream Products

Pharmaceutical Intermediates

Alpha-(2,4-Dichlorophenyl)-2-(1H-imidazole-1-yl) ethanol is a crucial intermediate in synthesizing various antifungal agents, such as Econazole and Miconazole. Its imidazole ring structure is commonly found in drugs targeting specific enzymes in pathogenic organisms, making it effective against fungal infections.

• Econazole – Used in topical antifungal medications for treating skin infections

• Miconazole – Employed in both prescription and OTC antifungal formulations

• Related Azole Derivatives – Building block for next-generation antifungal drug development

Agricultural Chemicals

This compound is also explored for its potential in agrochemicals, particularly in developing new fungicides. It helps protect crops from fungal diseases, contributing significantly to agricultural productivity.

• Fungicide Precursor – Core building block for developing broad-spectrum crop protection agents

• Structure-Activity Relationship (SAR) Optimization – Enables fine-tuning of biological activity in new fungicide development

Chemical Intermediates

Alpha-(2,4-Dichlorophenyl)-2-(1H-imidazole-1-yl) ethanol serves as a precursor in synthesizing various other chemical compounds. It is used in the production of complex organic molecules for different industrial processes.

Recent Research and Developments

Synthesis and Characterization

Recent advancements in synthetic methods have led to more efficient production routes for this compound, achieving higher yields and greater purity. This improvement has made it more accessible for industrial use.

Biological Activity

Research indicates that this compound exhibits promising antifungal properties, demonstrating efficacy against several fungal strains affecting humans and plants.

Environmental Impact

Ongoing studies are assessing the environmental impact of using this compound in agriculture. Researchers focus on its degradation pathways and environmental persistence to ensure safe application.

Market Outlook

Alpha-(2,4-Dichlorophenyl)-2-(1H-imidazole-1-yl) ethanol continues to be a strategically valuable intermediate for pharmaceutical and agrochemical industries. Ongoing improvements in synthesis efficiency, quality control, and application development ensure its continued relevance in industrial manufacturing processes.

For technical specifications, industrial-scale supply information, or custom synthesis inquiries, contact our technical team at inquiry@royal-chem.com.