Octadecenedioic Acid

• FDA UNII: 565ZMT5QRG

• InChIKey: SBLKVIQSIHEQOF-UPHRSURJSA-N

• COSING No.: 57554

• Appearance: Light yellow to white solid powder

• Assay (Purity): ≥ 98%

• Identification (NMR): Conforms to structure (H-NMR)

• Melting Point: 96–102°C

• Loss on Drying: ≤ 0.5%

COA provided with each shipment. Custom analytical testing (HPLC, GC-MS, elemental analysis) available upon request.

• Melting Point: 96–102°C

• Solubility: Soluble in DMSO (100 mg/mL)

• Form: Stable solid under normal conditions

Octadecenedioic Acid is an 18-carbon α,ω-unsaturated dicarboxylic acid with a cis-9 double bond. It is the ω-oxidation product of oleic acid, produced industrially via biofermentation using engineered Candida tropicalis strains. Structurally related to Azelaic Acid (C9) but with significantly different pharmacological properties due to its longer carbon chain and PPARγ binding capability.

The compound is registered in the FDA Substance Registration System (UNII: 565ZMT5QRG) and listed in multiple international cosmetic ingredient inventories (INCI, COSING, IECIC). It has been the subject of published research in pharmacology, dermatology, and polymer science.

Octadecenedioic Acid is a high-value specialty fine chemical with applications including:

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs). Its dual carboxylic acid functionality and unsaturated backbone make it a versatile intermediate for constructing complex molecular architectures.

• PPARγ Agonist & Metabolic Research: Demonstrated binding to all three PPAR subtypes, with particular affinity for PPARγ (EC₅₀ ~1×10⁻⁶ M). Used as a research tool in studies of lipid metabolism, insulin signaling, anti-inflammatory pathways, and melanogenesis regulation.

• Specialty Cosmetic Active: Listed in INCI, COSING, and IECIC international cosmetic ingredient inventories for functional skincare formulation development.

• Bio-based Polymer Materials: Used as a long-chain diacid monomer for developing bio-based polyamides, polyesters, and other green polymer materials.

• COA (Certificate of Analysis): Provided with every batch — purity, melting point, LOD, appearance, and NMR confirmation

• TDS (Technical Data Sheet): Full specifications and handling instructions

• SDS/MSDS (Safety Data Sheet): Available in GHS format for EU, US, and other markets

• Regulatory Support: FDA UNII, INCI, COSING, IECIC documentation to support your regulatory filings