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Trifluoroacetic Acid (TFA)

CAS NO. 76-05-1
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Product Name Trifluoroacetic Acid (TFA)
(Synonyms: Perfluoroacetic acid; TFAA)
CAS NO. 76-05-1
Formula & Weight CF3COOH (MW: 114.02)
Chemical Structure TFA Structure
Technical Specifications
  • Appearance: Clear, colorless fuming liqui

  • Assay: ≥ 99.9% (High Purity)

  • Water (Karl Fischer): ≤ 0.05% (Strictly controlled)

  • Chloride (Cl): ≤ 10 ppm

  • Sulphate (SO4): ≤ 10 ppm

  • Fluoride (F): ≤ 50 ppm

Key Applications

A critical reagent for Biotech and Analytical Chemistry:

  • Peptide Synthesis: The standard reagent for removing protecting groups (e.g., Boc/t-Bu) and cleaving peptides from solid-phase resins.

  • HPLC/LC-MS Analysis: Used as a mobile phase additive (0.1%) to improve peak shape and resolution for proteins and peptides.

  • Organic Synthesis: Acts as a strong acid catalyst and solvent for esterification, acylation, and polymerization reactions.

Packaging & Handling

Packaging: 250kg HDPE Drum / 25kg Fluorinated Drum / 500ml Glass Bottle

Safety: Corrosive Liquid (UN 2699). Use only in fume hood. Store in a cool, dry, ventilated place away from bases.

Need High Purity TFA for Synthesis?

Royalchem ensures Low Water Content (≤0.05%) for sensitive peptide cleavage.        
Safe Global Shipping in UN-approved containers.        
Request a Quote (Drum/Bottle)

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