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Trifluoroacetic Acid (TFA)

CAS NO. 76-05-1
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Product   Name Trifluoroacetic acid (TFA)
CAS NO 76-05-1
Molecular Formula CF3COOH
Structural Formula 76-05-1
Item Standard
Appearance Colorless liquid with a pungent odor
Molecular Weight 114.023
Trifluoroacetic acid   content ≥99.5% (Actual: 99.96%)
Boiling Point (1013   hPa) 72 °C
Hydrochloric acid   (HCl) ≤0.10% (Actual: 0.018%)
Sulfuric acid (H2SO4) ≤0.10% (Actual: 0.009%)
Hydrofluoric acid (HF) ≤0.01% (Actual: 0.005%)
Water content ≤0.10% (Actual: 0.08%)
Application Trifluoroacetic   acid (TFA) is extensively applied in organic synthesis, pharmaceuticals,   pesticide production, and the electronics sector. It is frequently used as a   reagent, solvent, and catalyst in organic synthesis.
    Specific Applications Include:
    Peptide Synthesis: TFA is a potent acid that plays a crucial role in   solid-phase peptide synthesis by cleaving protective groups from peptide   chains. Due to its volatility, it can be easily removed from reaction   mixtures, making it an optimal reagent for peptide synthesis.
    NMR Chemical Shift Reference Compound: TFA is a reference compound for   chemical shifts in nuclear magnetic resonance (NMR) spectroscopy.
    Additional Uses: TFA is also involved in synthesizing other fluorinated compounds   and acts as a solvent in various chemical processes.


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