Dibenzocyclooctyne (DBCO) is used for the azide alkyne cycloaddition (SPAAC) reaction without the catalysis of copper ions. DBCO series products include DBCO- acid, DBCO-amine, DBCO-PEG-COOH, DBCO-PEG-amine, and DBCO labeled biotin, fluorescent dyes and biochemical small molecules that can be used f