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Pyrazole

CAS NO. 288-13-1
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  • ≥99.0%

  • Royalchem

  • 288-13-1

Product Name Pyrazole (1H-Pyrazole)
CAS 288-13-1  |  EC No. 206-017-1
Synonyms: 1,2-diazole, 1H-1,2-diazole
Formula / MW C3H4N2 / 68.08
Structure Pyrazole 1H-Pyrazole structure CAS 288-13-1 nitrogen heterocycle intermediate
Product Type Five-membered aromatic heterocycle with two adjacent nitrogens; functionalized at N-1 and C-4 to make pharmaceutical, agrochemical and ligand building blocks.
Specification
  • Appearance: white to off-white crystals

  • Assay: ≥ 99.0%

  • Moisture: ≤ 0.50%

  • Melting point 67–70 °C; boiling point 186–188 °C (literature)

Typical values; the batch COA governs.
Applications
  • Pharmaceutical intermediates: converted to 4-bromopyrazole, 4-iodopyrazole and pyrazole-4-boronic acid pinacol ester — building blocks for pyrazole-containing kinase inhibitors such as JAK inhibitors

  • Ligands & catalysis: tris(pyrazolyl)borate (Tp, “scorpionate”) ligands and metal complexes

  • Agrochemical & fine chemicals: N-substituted pyrazole intermediates and functional molecules

Packing & Storage Fiber drums with double PE liners; pack size per order. Keep sealed, dry and away from light and strong oxidizers, in a cool, ventilated place.
Sourcing pyrazole?
Royalchem supplies Pyrazole (CAS 288-13-1), assay ≥99.0%, moisture ≤0.50%, with batch COA, SDS and dangerous-goods shipping documents; FOB / CIF worldwide. Please state your application, single-impurity limits and quantity.

FAQ

What is pyrazole? Pyrazole (CAS 288-13-1, C3H4N2, MW 68.08) is a five-membered aromatic ring with two adjacent nitrogens — a basic building block for pharmaceutical, agrochemical and ligand chemistry.
Pyrazole vs imidazole — what's the difference? Same formula (C3H4N2), different isomers: pyrazole has adjacent 1,2-nitrogens; imidazole has 1,3-nitrogens (CAS 288-32-4). Basicity, reactivity and uses differ — always check the CAS number.
Is pyrazole used to make celecoxib or fipronil? Not directly. Celecoxib, fipronil and SDHI fungicides contain a pyrazole ring, but industrially that ring is built from substituted hydrazines and diketones or esters, not from pyrazole itself. Pyrazole is mainly used for 4-halo- and 4-boryl-pyrazole building blocks and Tp ligands.
Pyrazole vs 3,5-dimethylpyrazole? 3,5-Dimethylpyrazole (CAS 67-51-6) carries two methyl groups and is mainly an isocyanate blocking agent. Royalchem supplies both.
Can you provide COA, SDS and samples? Yes. Batch COA and SDS with every shipment; samples on request.
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