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Intermediate grade, ≥99.0%
Royalchem
137-00-8
4-Methyl-5-thiazoleethanol (Sulfurol, CAS 137-00-8) is a thiazole alcohol used as a FEMA 3204 meaty / nutty flavor ingredient and as the key intermediate for clomethiazole and vitamin B1 (thiamine). Royalchem supplies it at ≥99.0% (GC) with batch COA, SDS and samples.
| Product Name | 4-Methyl-5-thiazoleethanol (Sulfurol) 5-(2-Hydroxyethyl)-4-methylthiazole Also: 4-methyl-5-(β-hydroxyethyl)thiazole, 2-(4-methylthiazol-5-yl)ethanol, MHT |
| Identifiers | CAS 137-00-8 | EC No. 205-272-6 | FEMA 3204 | JECFA 1031 |
| Formula / MW | C6H9NOS / 143.21 |
| Structure | |
| Product Type | Flavor ingredient and synthesis intermediate. The primary hydroxyl is the reactive site (chlorination gives clomethiazole; acetylation gives the acetate ester), and the ring nitrogen forms thiazolium salts. Not an API or a compounded flavor. |
| Item | Specification |
| Appearance | Pale yellow to yellowish liquid |
| Assay (GC) | ≥ 99.0% |
| Water (KF) | ≤ 0.5% |
| Freezing point | ≥ 5 °C |
| Refractive index (nD20) | 1.540 – 1.556 |
Typical values; the batch COA governs.
Flavors (FEMA 3204 / JECFA 1031): meaty, roasted note that turns nutty on dilution — used in savory, meat, nut, chocolate and bakery flavors.
Clomethiazole: chlorination of the hydroxyl gives 5-(2-chloroethyl)-4-methylthiazole, the sedative / anticonvulsant API.
Vitamin B1 (thiamine): the thiazole half of the thiamine molecule.
Thiazolium catalysts and esters: N-benzyl / N-ethyl thiazolium salts for benzoin and Stetter reactions; 4-methyl-5-thiazoleethanol acetate (CAS 656-53-1).
| Packing | Sealed drums; pack size per order. |
| Storage | Cool, dry and ventilated, away from light, heat and oxidizers. May solidify in cold weather — warm the closed drum gently and mix before use. Shelf life 12 months unopened. |
| Transport | Non-hazardous cargo, no UN number; flash point 112 °C (closed cup). Some SDS list GHS Warning (H315 / H319 / H335) — wear gloves and eye protection. Batch SDS governs. |
| What is CAS 137-00-8? | 4-Methyl-5-thiazoleethanol (Sulfurol), C6H9NOS, MW 143.21 — a pale yellow liquid, density about 1.196 g/mL, bp 135 °C at 7 mmHg, soluble in water and alcohol. Used as a flavor ingredient and as a clomethiazole / vitamin B1 intermediate. |
| Is Sulfurol an approved flavoring substance? | It is listed as FEMA GRAS 3204 and evaluated by JECFA (No. 1031). For food use, confirm the grade and your local regulatory status before purchase. |
| How is it converted to clomethiazole? | Replacing the hydroxyl with chlorine (thionyl chloride or PCl5) gives 5-(2-chloroethyl)-4-methylthiazole. Alkylating the ring nitrogen instead gives thiazolium salts; the same step with the pyrimidine unit builds thiamine. |
| Is it hazardous to ship? | No UN number; it ships as general cargo. Handle as a mild irritant per the SDS. |
| Can you provide COA, SDS and samples? | Yes. Batch COA and SDS come with every shipment; samples are available on request. |
