5-Fluoro-4-hydrazino-2-methoxypyrimidine

Name: 5-Fluoro-4-hydrazino-2-methoxypyrimidine
Brand: Royalchem
Rating: 5.0 (63 reviews)

CAS NO. 166524-64-7

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Model:
Agrochemical Intermediate Grade ≥98.5%
Brand:
Royalchem
Code:
166524-64-7

Product Description

Product Name	5-Fluoro-4-hydrazino-2-methoxypyrimidine (Synonyms: 2-Methoxy-4-hydrazino-5-fluoropyrimidine; 5-Fluoro-4-hydrazinyl-2-methoxypyrimidine)
CAS NO.	166524-64-7
Formula & Molecular Weight	C₅H₇FN₄O (MW: 158.13)
Chemical Structure
Product Type	Fluorinated Pyrimidine Agrochemical Intermediate / Florasulam Intermediate A functionalized pyrimidine building block used in the preparation of fluorinated triazolopyrimidine intermediates for agrochemical synthesis.
Typical Specifications	Royalchem current typical specification; final analytical results are subject to the actual batch COA. Appearance: Off-white to light yellow powder Assay: ≥98.5% Loss on Drying: ≤0.30%
Reference Properties	Physical Form: Solid / crystalline powder Published Melting Point: Approximately 187–189°C Chemical Class: Fluorinated hydrazinopyrimidine Published physical-property data are provided for substance identification and reference only. Commercial acceptance criteria should follow the applicable supplier specification and batch COA.
Key Applications	The principal documented industrial application of5-Fluoro-4-hydrazino-2-methoxypyrimidineis as an intermediate in the synthesis ofFlorasulam and related triazolopyrimidine sulfonamide herbicide chemistry. Florasulam Intermediate:Used as an important fluorinated pyrimidine intermediate in synthetic routes leading to Florasulam. Triazolopyrimidine Ring Formation:The hydrazino functionality can be converted through cyclization chemistry to build the fluorinated methoxy-triazolopyrimidine heterocyclic core. Triazolopyrimidine Sulfonamide Herbicides:Relevant to process development and manufacture of agrochemical intermediates containing the fluorinated triazolopyrimidine scaffold. Fluorinated Heterocycle Synthesis:May be used as a specialized building block where a 5-fluoro, 2-methoxy and hydrazino-substituted pyrimidine structure is required.
Packaging, Storage & Shipping	Packaging:Commercial packaging is selected according to product grade, order quantity and supplier specification. Final package size and container type are confirmed with the commercial order. Storage:Keep containers tightly closed in a cool, dry and well-ventilated area. Protect from moisture and incompatible materials. Detailed storage conditions should follow the applicable supplier TDS/SDS.

Sourcing a Florasulam Intermediate?

Royalchem supplies5-Fluoro-4-hydrazino-2-methoxypyrimidine (CAS 166524-64-7)for agrochemical and fluorinated heterocycle synthesis. Our current typical specification includesassay ≥98.5% and loss on drying ≤0.30%. Batch-specificCOA, SDS, specification confirmation and international sourcing supportare available for commercial inquiries.
Contact Royalchem with your target downstream product, purity / impurity requirements and quantity for specification matching and quotation.

Role in Florasulam Synthesis

Starting Intermediate	5-Fluoro-4-hydrazino-2-methoxypyrimidine provides the fluorinated methoxy-pyrimidine structure and reactive hydrazino group required for subsequent heterocycle construction.
Cyclization	Published Florasulam-related processes convert the hydrazinopyrimidine structure into a fluorinated methoxy-triazolopyrimidine ring system.
Downstream Intermediate	The resulting triazolopyrimidine chemistry can be further converted to sulfonyl chloride intermediates used in the manufacture of Florasulam.

Typical Quality Specifications

Test Item	Typical Specification
Appearance	Off-white to light yellow powder
Assay, %	≥98.5
Loss on Drying, %	≤0.30

Typical Royalchem specification. Analytical method, impurity profile and final results are subject to the applicable supplier specification and actual batch COA.

Frequently Asked Questions

What is CAS 166524-64-7?	CAS 166524-64-7 is 5-Fluoro-4-hydrazino-2-methoxypyrimidine, a fluorinated hydrazinopyrimidine used as an agrochemical synthesis intermediate.
Is it a Florasulam intermediate?	Yes.Published synthesis patents identify 2-Methoxy-4-hydrazino-5-fluoropyrimidine / 5-Fluoro-4-hydrazino-2-methoxypyrimidine as an important intermediate used in Florasulam synthesis.
Is this product Florasulam itself?	No.It is a chemical intermediate used upstream in Florasulam synthesis. Florasulam has a different molecular structure and CAS number.
What is its relationship with 5-Fluorouracil?	Published process routes have used 5-Fluorouracil as an upstream starting material, followed by chlorination, methoxylation and hydrazinolysis steps to obtain the fluorinated hydrazinopyrimidine intermediate.
What melting point should be expected?	Published patent examples report approximately 187–189°C. Melting point should be treated as reference identification data unless it is included in the agreed commercial specification.
Is ≥98.5% suitable for every Florasulam process?	Not necessarily. Process requirements can differ in assay, individual impurities, total impurities and moisture / loss on drying. Customers should provide their target specification for grade matching.
Can Royalchem provide COA and SDS?	Batch-specific COA, SDS and specification information can be provided according to the actual commercial supply source. Customers are encouraged to provide their downstream application, impurity requirements and target quantity when requesting a quotation.