5-Fluorouracil

CAS NO. 51-21-8

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Product Name	5-Fluorouracil (5-FU) (Fluorouracil / 5-Fluoro-2,4(1H,3H)-pyrimidinedione)
CAS NO.	51-21-8
Formula & Weight	C4H3FN2O2 (MW: 130.08)
Chemical Structure
Specification (USP/EP)	Appearance: White or practically white, crystalline powder Assay (HPLC): ≥ 99.0% (Dried Basis) Loss on Drying: ≤ 0.5% Residue on Ignition: ≤ 0.1% Heavy Metals: ≤ 20 ppm Melting Point: 280°C - 282°C (Decomposes) Solubility: Sparingly soluble in water; slightly soluble in alcohol.
Applications	A pyrimidine analogue that acts as an antimetabolite: Antineoplastic API: Inhibits thymidylate synthase (TS), blocking DNA synthesis. Widely used in chemotherapy for colorectal, breast, and skin cancers. Synthesis Intermediate: Key precursor for the synthesis of Flucytosine (5-FC) and other fluorinated nucleosides. Research Grade: Used in biochemical studies of nucleic acid metabolism and plant growth differentiation (e.g., rice/wheat genetic metabolism).
Packaging & Storage	Packaging: 25kg Fiber Drum / 1kg Foil Bag. Storage: Store in tight, light-resistant containers. Avoid high temperatures (stored at room temperature or 2-8°C per request).