α-(2,4-Dichlorophenyl)-1H-imidazole-1-ethanol

Name: α-(2,4-Dichlorophenyl)-1H-imidazole-1-ethanol
Brand: Royalchem
Rating: 5.0 (15 reviews)

CAS NO. 24155-42-8

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Model:
Pharmaceutical intermediate grade, ≥99.0%
Brand:
Royalchem
Code:
24155-42-8

Product Description

Product Name	α-(2,4-Dichlorophenyl)-1H-imidazole-1-ethanol 1-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-yl)ethanol CAS 24155-42-8 \| EC No. 246-042-5 Synonyms: imidazole ethanol, miconazole intermediate, econazole intermediate, 2,4-dichloro-α-(1H-imidazol-1-ylmethyl)benzyl alcohol
Formula / MW	C₁₁H₁₀Cl₂N₂O / 257.11
Structure
Product Type	Key intermediate for imidazole antifungal APIs. The secondary alcohol is the etherification site: reaction with the corresponding benzyl chloride gives miconazole, econazole, isoconazole or sulconazole. Supplied for API synthesis; not an API or finished drug.
Specification
Item	Specification
Appearance	White to off-white crystalline powder
Assay (GC)	≥ 99.0%
Total impurities	≤ 0.10%
Melting point	134 – 138 °C
Loss on drying	≤ 0.20%
Sulfated ash	≤ 0.10%

Typical values; the batch COA governs.

Applications	Miconazole (nitrate): etherification with 2,4-dichlorobenzyl chloride — broad-spectrum topical antifungal Econazole (nitrate): etherification with 4-chlorobenzyl chloride — topical antifungal Isoconazole, sulconazole and related azoles: same intermediate, different benzyl halide R&D: SAR studies of imidazole antifungals and impurity reference standards
Packing & Storage	Fiber drums with double PE liners; pack size per order. Keep sealed, away from light and moisture, in a cool, dry, ventilated place.
Transport	Shipped as general (non-hazardous) cargo, no UN number. GHS Warning (H302 harmful if swallowed; H319 eye irritation; some SDS also list H315/H335 and aquatic toxicity) — avoid dust, wear gloves and eye protection; batch SDS governs.

Sourcing a miconazole / econazole intermediate?
Royalchem supplies α-(2,4-Dichlorophenyl)-1H-imidazole-1-ethanol (CAS 24155-42-8), assay ≥99.0% (GC), total impurities ≤0.10%, with batch COA, SDS and samples; FOB / CIF shipping worldwide. Please state your target API, single-impurity limits and quantity.

FAQ

What is CAS 24155-42-8?	α-(2,4-Dichlorophenyl)-1H-imidazole-1-ethanol (1-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-yl)ethanol), C₁₁H₁₀Cl₂N₂O, MW 257.11 — the shared key intermediate for miconazole, econazole and related imidazole antifungals.
How is it converted to miconazole and econazole?	The secondary hydroxyl is etherified with a benzyl chloride under basic conditions: 2,4-dichlorobenzyl chloride gives miconazole, 4-chlorobenzyl chloride gives econazole; the same route yields isoconazole and sulconazole.
Is it chiral? Is the racemate supplied?	It has one stereocenter. The commercial intermediate and the miconazole / econazole APIs are racemic; this product is the racemate.
Is it hazardous to ship?	No UN number; ships as general cargo. GHS Warning (harmful if swallowed, eye irritant) — standard solid-chemical handling per the SDS.
Can you provide COA, SDS and samples?	Yes. Batch COA and SDS are provided with each shipment; samples can be arranged for evaluation.