Methyl Oxalyl Chloride

CAS NO. 5781-53-3

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Product Name	Methyl Oxalyl Chloride (Synonyms: Methyl chlorooxoacetate; Methyl chloroglyoxylate)
CAS NO.	5781-53-3
Formula & Weight	C3H3ClO3 (MW: 122.51)
Chemical Structure
Technical Specifications	Appearance: Colorless to slightly yellow transparent liquid Purity (GC): ≥ 99.0% Boiling Point: 118-120°C Density: 1.33 g/mL at 25°C Solubility: Soluble in benzene, chloroform, ether. Decomposes in water.
Key Applications	Versatile building block for high-value synthesis: 1. Pharmaceutical Synthesis Key intermediate for HIV medications (e.g., Dolutegravir related pathways). Synthesis of substituted isoxazoles for antibiotic production. Precursor for fused coumarin derivatives. 2. Agrochemical Industry Critical for synthesizing Sulfonylurea herbicides. Used in the production of high-efficiency crop protection agents. 3. Organic Synthesis Powerful acylating agent for introducing methoxalyl groups. Facilitates intramolecular Wittig reactions.
Handling & Storage	Warning: Strong lachrymator (Tear Gas effect). Storage: Strictly moisture sensitive. Keep container tightly closed in a dry and well-ventilated place. Store under inert gas (Nitrogen/Argon).