Ethyl Oxalyl Chloride (Ethyl Chloroglyoxylate)

Name: Ethyl Oxalyl Chloride (Ethyl Chloroglyoxylate)
Brand: Royalchem
Rating: 5.0 (66 reviews)

CAS NO. 4755-77-5

Availability:

Quantity:



Inquire Add to Basket PDF Export

Model:
Industrial / Synthesis Grade ≥98%
Brand:
Royalchem
Code:
4755-77-5

Product Description

Product Name	Ethyl Oxalyl Chloride (Ethyl Chloroglyoxylate) (Synonyms: Ethyl Chlorooxoacetate; Monoethyl Oxalyl Chloride; Oxalic Acid Monoethyl Ester Chloride; Chloroglyoxylic Acid Ethyl Ester)
CAS NO.	4755-77-5
Formula & Molecular Weight	C₄H₅ClO₃ (MW: 136.53) \| EC: 225-285-0 \| MDL: MFCD00000706
Chemical Structure
Product Type	Acyl Chloride / Acylating Reagent / α-Carbonyl Ester Building Block Ethyl Oxalyl Chloride contains both a reactive acyl chloride group and an ethyl ester group, making it useful for introducing the –CO–COOEt structural unit into organic molecules.
Typical Specification	Typical reference specification. Final analytical results are subject to the applicable supplier specification and actual batch COA. Appearance: Colorless to almost colorless clear liquid Assay: ≥98.0%
Reference Properties	Physical State: Liquid at room temperature Boiling Point: Approx. 135°C Density / Specific Gravity: Approx. 1.22–1.23 Refractive Index: Approx. 1.416–1.42 Flash Point: Approx. 41°C Moisture Sensitivity: Moisture sensitive; decomposes on contact with water.
Key Applications	Ethyl Oxalyl Chloride is a reactiveacylating reagent and carbonyl building blockused in fine chemical and advanced organic synthesis. α-Keto Ester Synthesis:Used for the preparation of α-keto esters and related carbonyl compounds by introducing the –CO–COOEt structural unit. Arylglyoxylate Chemistry:Used in Friedel–Crafts acylation routes leading to substituted arylglyoxylic acid and related aromatic α-carbonyl derivatives. 3-Pyrrolin-2-one Synthesis:Reported as a building block in the synthesis of functionalized 3-pyrrolin-2-one heterocycles. Quinoxalinone Synthesis:Used in synthetic routes to quinoxalinone and related nitrogen-containing heterocyclic derivatives. Phenanthrenequinone Derivatives:Used in published synthetic routes for substituted 9,10-phenanthrenequinone structures. Fine Chemical Process Development:Its reactive acyl chloride functionality makes it useful in pharmaceutical, agrochemical and other fine-chemical R&D where ethoxyoxalyl or α-carbonyl ester functionality is required.
Packaging, Storage & Shipping	Packaging:Commercial packaging is selected according to product grade, order quantity and dangerous-goods requirements. Final package size and container type are confirmed with the commercial order. Storage:Keep containers tightly closed and protect from moisture. Store in a cool, dry and well-ventilated area away from heat, sparks and open flames. Reference supplier information recommends inert-gas storage for moisture-sensitive handling. Exact storage temperature should follow the applicable TDS/SDS.

Sourcing Ethyl Oxalyl Chloride for Fine Chemical Synthesis?

Royalchem suppliesEthyl Oxalyl Chloride (Ethyl Chloroglyoxylate, CAS 4755-77-5)for fine chemical and advanced organic synthesis. Typical applications includeα-keto ester synthesis, arylglyoxylate chemistry and heterocycle synthesis. Batch-specificCOA, SDS, specification confirmation and international logistics supportare available for commercial inquiries.
Contact Royalchem with your target application, required assay / impurity limits, quantity and destination country for specification and logistics matching.

How Ethyl Oxalyl Chloride Works in Organic Synthesis

Reactive Acyl Chloride	The acyl chloride carbonyl is highly electrophilic and can react with suitable nitrogen, oxygen and carbon nucleophiles in acylation chemistry.
α-Carbonyl Ester Unit	Ethyl Oxalyl Chloride introduces a carbonyl plus ethyl ester unit, making it useful for α-keto ester and glyoxylate-type intermediate synthesis.
Friedel–Crafts Acylation	In suitable Lewis-acid-mediated systems, Ethyl Chloroglyoxylate can participate in aromatic acylation to generate arylglyoxylate-type structures.
Heterocycle Construction	The resulting carbonyl intermediates can undergo condensation, cyclization, amination and other transformations for the construction of complex nitrogen-containing heterocycles.

Ethyl Oxalyl Chloride vs Methyl Oxalyl Chloride

Item	Ethyl Oxalyl Chloride	Methyl Oxalyl Chloride
CAS	4755-77-5	5781-53-3
Molecular Weight	136.53	122.50
Ester Group	Ethyl ester / –COOEt	Methyl ester / –COOMe
Can They Be Substituted Directly?	Not automatically.They share related acyl chloride chemistry, but they generate different ester-containing products. Reaction conditions, purification and downstream chemistry should be evaluated for the specific synthetic route.

Frequently Asked Questions

What is CAS 4755-77-5?	CAS 4755-77-5 is Ethyl Oxalyl Chloride, commonly also called Ethyl Chloroglyoxylate, Ethyl Chlorooxoacetate or Monoethyl Oxalyl Chloride.
What is Ethyl Oxalyl Chloride mainly used for?	It is mainly used as a reactive acylating reagent and carbonyl building block for α-keto esters, arylglyoxylates, nitrogen-containing heterocycles and other fine chemical intermediates.
Is Ethyl Oxalyl Monochloride the same as Ethyl Chloroglyoxylate?	Yes.These names are used for the same substance with CAS 4755-77-5. Ethyl Oxalyl Chloride and Ethyl Chlorooxoacetate are also commonly used names.
Is it a specific Cefazolin or Cefamandole intermediate?	Ethyl Oxalyl Chloride is widely used as a general acylating and carbonyl-building reagent in pharmaceutical and fine-chemical synthesis. Suitability for any specific API route should be confirmed against the customer's actual process rather than inferred solely from the CAS number.
Why must Ethyl Oxalyl Chloride be protected from moisture?	Its acyl chloride functionality is highly moisture sensitive. Reference SDS information states that the material decomposes in contact with water and may release hazardous decomposition gases, so dry handling is important.
Can Royalchem provide COA and SDS?	Batch-specific COA, SDS and specification information can be provided according to the actual commercial supply source. Customers should provide the target application, assay / impurity requirements, quantity and destination when requesting a quotation.