2,5-Dihydro-2,5-Dimethoxyfuran

• Appearance: Colorless to light yellow transparent liquid (mixture of cis and trans isomers)

• Purity (GC): ≥ 97.0%

• Water Content: ≤ 1.0%

• Refractive Index: 1.434

• Boiling Point: 160–162°C

• Melting Point: < −40°C

• Density (20°C): 1.073 g/cm³

• Stability: Stable under normal temperatures and pressures

2,5-Dihydro-2,5-Dimethoxyfuran (CAS 332-77-4) is a dihydrofuran derivative bearing two methoxy groups at the 2- and 5-positions, commercially supplied as a mixture of cis and trans isomers. It is the direct upstream precursor to 2,5-Dimethoxytetrahydrofuran (DMTHF, CAS 696-59-3) — catalytic hydrogenation of DMDF yields DMTHF.

The compound is manufactured by electrolytic methoxylation of furan in methanol solution. A greener photocatalytic route using biomass-derived furan under visible light has also been developed. DMDF serves as a versatile masked 1,4-dicarbonyl equivalent and is a critical industrial intermediate in the tropane alkaloid synthesis chain.

DMDF is an intermediate in the tropane alkaloid synthesis chain. Key applications include:

• Atropine Sulfate Synthesis: Upon acid-catalyzed hydrolysis with HCl, DMDF yields 2-hydroxy-1,4-butanedial, which is further hydrogenated and rehydrolyzed to produce succinaldehyde (butanedial) — the key C4 dialdehyde building block in the Robinson tropinone synthesis. Atropine Sulfate is a widely used anticholinergic drug in ophthalmology, anesthesiology, emergency medicine, and organophosphate poisoning treatment.

• Anisodamine Hydrobromide (654-2) Synthesis: DMDF is also a key intermediate for the production of Anisodamine Hydrobromide, an important anticholinergic agent used to improve microcirculation and treat septic shock, widely prescribed in China and emerging markets.

• DMTHF Production: Catalytic hydrogenation of DMDF produces 2,5-Dimethoxytetrahydrofuran (DMTHF, CAS 696-59-3), which is itself a major pharmaceutical and pyrrole synthesis intermediate.

• COA (Certificate of Analysis): Provided with every batch — purity, water content, refractive index, appearance, and density

• TDS (Technical Data Sheet): Full specifications, physical properties, and handling guidelines

• SDS/MSDS (Safety Data Sheet): Available in GHS format for EU, US, and other markets