2,5-Dimethoxytetrahydrofuran

• Appearance: Colorless to light yellow volatile liquid (mixture of cis and trans isomers)

• Assay (GC): ≥ 98.0%

• Moisture: ≤ 0.5%

• Refractive Index (20°C): 1.350–1.450

• Boiling Point: 145–147°C

• Melting Point: −45°C

• Density (20°C): 1.02 g/cm³

• Flash Point: 38°C (closed cup)

• Solubility: Miscible with water, ethanol, and diethyl ether; soluble in dichloromethane, toluene, chloroform, and methanol

2,5-Dimethoxytetrahydrofuran (CAS 696-59-3) is a versatile tetrahydrofuran (THF) derivative with two methoxy groups at the 2- and 5-positions, existing as a mixture of cis and trans isomers. It serves as a stable, masked form of succinaldehyde (butanedial). Key applications include:

• Tropinone & Atropine Sulfate Synthesis: Critical starting material for the Robinson tropinone synthesis. Upon acid-catalyzed hydrolysis, DMTHF releases succinaldehyde — the key C4 building block. Tropinone is an essential precursor to Atropine Sulfate, widely used in ophthalmology, anesthesiology, and emergency medicine.

• Paal-Knorr & Clauson-Kaas Pyrrole Synthesis: Acts as a masked 1,4-dicarbonyl equivalent for the preparation of N-substituted pyrroles under mild conditions using catalysts such as FeCl₃, P₂O₅, CAN, montmorillonite, or I₂. One of the most established routes for pyrrole ring construction in medicinal chemistry and materials science.

• Pharmaceutical Intermediates: Used in the synthesis of antiviral agents (e.g. Oxetanocin A), antibiotics, and as a reference impurity standard for the MRI contrast agent Gadobutrol.

• Agrochemical Intermediates: Synthesis precursor for crop protection agents and pesticide active ingredients.

• COA (Certificate of Analysis): Provided with every batch — assay, moisture, refractive index, appearance, and density

• TDS (Technical Data Sheet): Full specifications, physical properties, and handling guidelines

• SDS/MSDS (Safety Data Sheet): Available in GHS format for EU, US, and other markets